Bacterial magnetic particles – wide range of applications in biomedicine and -technology
2021-03-03
A new innovative field of application in biomedicine and biotechnology using magnetic nanoparticles (magnetosomes) from bacteria is emerging. An interdisciplinary research team from the University of Bayreuth (Microbiology, Physical Chemistry & Bioprocess Technology) in cooperation with the North Bavarian NMR Centre optimised an isolation procedure and established high quality control parameters to extract intact magnetosomes gently and to purify the isolate.The new standardised purification protocol and the reproducibility of the process enable the production of larger quantities. Furthermore, the University of Jena evaluated possible cytotoxicity of the isolated particles in mammalian cells. The field of application could range from imaging diagnostics to the targeted use of medical agents, such as in cancer therapy. More details can be found in the press release of the UBT or in the publication of Sabine Rosenfeldt et al. Towards standardized purification of bacterial magnetic nanoparticles for future in vivo applications. Acta Biomaterialia (2021), Vol. 120, 293-303.